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When Bio Meets Technology: Biohybrid Neural Interfaces.

Amy E Rochford1, Alejandro Carnicer-Lombarte1, Vincenzo F Curto1

  • 1Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.

Advanced Materials (Deerfield Beach, Fla.)
|September 14, 2019
PubMed
Summary
This summary is machine-generated.

Biohybrid implants combine electronics with cultured cells for better nervous system interfacing. These devices offer improved tissue integration and long-term stability for neural applications.

Keywords:
biohybrid interfacescell transplantationimplantable devicesnervous system injuryneural interfaces

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Implantable Electronics

Background:

  • Electrode arrays are used for studying cells in culture or for tissue repair.
  • Traditional devices are specialized for either in vitro cell study or in vivo implantation.
  • Biohybrid implants integrate cultured cells with electrode arrays for enhanced functionality.

Purpose of the Study:

  • To provide an overview of current research in biohybrid devices.
  • To discuss the historical development of these technologies.
  • To explore applications based on host anatomical location (CNS, PNS, special senses).

Main Methods:

  • Review of existing literature on biohybrid implantable electrode arrays.
  • Categorization of devices based on anatomical targets (Central Nervous System, Peripheral Nervous System, special senses).
  • Analysis of the role of cellular components in mediating the electrode-tissue interface.

Main Results:

  • Biohybrid implants leverage cellular integration for improved electrode-tissue interface.
  • These devices show potential for enhanced tissue integration and long-term stability.
  • Research is advancing across different anatomical locations, including CNS, PNS, and special senses.

Conclusions:

  • Biohybrid implants represent a promising advancement in neural interfacing.
  • Cellular components offer unique advantages for implantable electronic devices.
  • Key challenges and future research directions for biohybrid technology are identified.