[DYNAMICS OF CHANGES IN THE MACROSTRUCTURE OF MACROPHAGE CELLS OF THE WOUND CHANNEL AFTER A GUNSHOT WOUND]

The purpose of this study was to identify the features of skeletal muscle macrophagocytic submicroscopic architectonics, the dynamics of transformations of organelles and intracellular membranes at different time after the simulated gunshot wound. The study involved 26 breeding rabbits. Gunshot wounds were inflicted from a Fort 12 pistol. Rabbits were removed from the experiment on the 30th and 60th day, after the application of wounds. Ultrathin sections, after contrasting with lead citrate, were examined under an EM-125 electron microscope at an accelerating voltage of 75 kV, with an increase of 42,000-72,000. Electronic microscopic studies of macrophagocyte organelles taken from the scar tissue of the wound channel on the thirtieth day after a gunshot wound revealed a large number of macrophage cells that are in a state of high functional activity, dystrophic and destructive changes of organelles with focal disruption of the membrane of the nucleus, mitochondria and the granular endoplasmatic reticulum reticulation. The course of catabolic processes caused by the presence in the wound channel of toxic components, destroyed myosymplasts and heavy metal ions of the damaging element. On the sixtieth day after a gunshot wound, the increased activity of macrophage cells remained, due to sluggish current processes of utilization of the destroyed ultrastructural components of myosymplasts and heavy metal ions from the damaging element.