[Function of tumor infiltrating lymphocytes in solid tumors - a review]

Area of Science:

• Oncology
• Immunology
• Cancer Research

Background:

• Solid tumors pose a significant global health challenge, with current treatments often failing to achieve complete eradication, leading to recurrence.
• Tumor immunotherapy offers a promising alternative by leveraging the host immune system to combat cancer.
• Adoptive immunotherapy and immune checkpoint inhibitors have demonstrated success in inducing durable, antigen-specific anti-tumor responses.

Purpose of the Study:

• To review the recent advancements in the application of tumor infiltrating lymphocytes (TILs) for treating solid tumors.
• To highlight the critical role of TILs in anti-tumor immunity and their correlation with patient prognosis.
• To explore the potential of TILs-based adoptive immunotherapy as a therapeutic strategy.

Main Methods:

• Review of recent scientific literature on tumor infiltrating lymphocytes (TILs).
• Analysis of studies investigating the role of TILs in tumorigenesis and treatment response.
• Examination of clinical outcomes associated with adoptive TILs immunotherapy in solid tumors.

Main Results:

• Tumor infiltrating lymphocytes (TILs) are integral to host antigen-specific anti-tumor immune responses.
• TILs exhibit a strong correlation with patient prognosis throughout cancer development and treatment.
• Adoptive immunotherapy utilizing TILs has shown significant efficacy across various solid tumors.

Conclusions:

• Tumor infiltrating lymphocytes (TILs) represent a vital component of effective cancer immunotherapy.
• TILs-based adoptive immunotherapy demonstrates considerable promise for improving outcomes in solid tumor patients.
• Further research into TILs is crucial for optimizing cancer treatment strategies.