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Frailty as Cardiovascular Risk Factor (and Vice Versa)
1National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani 2, 35128, Padua, Italy. nicola.veronese1@aulss3.veneto.it.
Advances in Experimental Medicine and Biology
|January 3, 2020
Summary
Frailty significantly increases the risk of cardiovascular disease (CVD) and related fatal events, particularly in older adults. Cardiovascular disease may also contribute to the development of frailty.
Area of Science:
- Geriatric Medicine
- Cardiovascular Research
- Public Health
Background:
- Frailty and cardiovascular disease (CVD) exhibit a high prevalence in older populations.
- A bidirectional relationship between frailty and CVD is suggested by epidemiological data.
Purpose of the Study:
- To review and discuss the current literature on the association between frailty and incident cardiovascular disease.
- To explore CVD as a potential risk factor for incident frailty.
Main Methods:
- Review of longitudinal studies and meta-analyses.
- Analysis of findings linking frailty domains to CVD onset.
- Discussion of existing literature on CVD as a risk factor for frailty.
Main Results:
- Frailty is an independent risk factor for incident CVD, especially fatal events.
- Specific frailty components (exhaustion, low physical activity, slow gait, weakness) are linked to CVD onset.
- Evidence suggests CVD may also be a risk factor for developing frailty.
Conclusions:
- Frailty is a significant predictor of cardiovascular disease in older adults.
- The interplay between frailty and CVD is a critical area in geriatric medicine.
- Further research is needed to fully elucidate the causal pathways between CVD and frailty.
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