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Plausible Links Between Metabolic Networks, Stem Cells, and Longevity
Magdalena Kucia1,2, Mariusz Z Ratajczak3,4
1Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA. mjkuci01@louisville.edu.
Advances in Experimental Medicine and Biology
|January 4, 2020
Summary
Aging causes decline in bodily functions, influenced by genetics and lifestyle. This chapter explores stem cell aging, hormonal effects, longevity, and potential anti-aging strategies for a healthier lifespan.
Area of Science:
- Gerontology and Stem Cell Biology
- Molecular Biology and Genetics
- Endocrinology and Metabolism
Background:
- Aging is a natural process involving functional decline in tissues and organs across multicellular organisms.
- Risk factors like obesity, diabetes, and inactivity accelerate aging and cardiovascular decline, impacting lifespan.
- Aging research has advanced significantly, identifying genetic and biochemical pathways that regulate the aging process.
Purpose of the Study:
- To examine the intricate relationship between stem cell biology and the aging process.
- To elucidate the role of endocrine regulation in stem cell aging and longevity.
- To provide an overview of current anti-aging modalities and epigenetic modifications linked to aging.
Main Methods:
- Review of current literature on cellular hallmarks of aging.
- Analysis of endocrine system's impact on stem cell compartments.
- Exploration of genetic pathways and biochemical processes influencing aging rate.
- Discussion of epigenetic modifications and emerging anti-aging interventions.
Main Results:
- Identification of key cellular hallmarks contributing to organismal aging.
- Understanding of how endocrine factors modulate stem cell function and aging.
- Recognition of genetic and epigenetic factors influencing longevity.
- Overview of potential therapeutic strategies targeting aging processes.
Conclusions:
- Stem cell aging is a critical factor in organismal aging, influenced by genetic and endocrine pathways.
- Epigenetic modifications play a significant role in the aging process and longevity.
- Emerging anti-aging modalities offer potential for interventions to mitigate age-related decline.
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