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Updated: Dec 28, 2025

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
Published on: September 20, 2014
The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development
Shahrzad Bahrampour1,2, Stefan Thor3
1The Hospital for Sick Children, Peter Gilgan Center for Research and Learning, Toronto, ON, Canada. shahrzad.bahrampour@sickkids.ca.
Abstract:
During central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have revealed that the Notch signal transduction pathway plays at least five different and distinct roles during these events. Herein, we review these many faces of Notch signalling and discuss the mechanisms that ensure context-dependent and compartment-dependent signalling. We conclude by discussing some outstanding issues regarding Notch signalling in this system, which likely have bearing on Notch signalling in many species.
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