Related Experiment Video
Updated: Dec 27, 2025

09:33
Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
Published on: March 21, 2025
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Mass spectrometry reveals the assembly pathway of encapsulated ferritins and highlights a dynamic ferroxidase
Jennifer Ross1, Thomas Lambert, Cecilia Piergentili
1EaStCHEM School of Chemistry, The University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, Scotland, UK. Dave.clarke@ed.ac.uk.
Abstract:
Encapsulated ferritins (EncFtn) are a recently characterised member of the ferritin superfamily. EncFtn proteins are sequestered within encapsulin nanocompartments and form a unique biological iron storage system. Here, we use native mass spectrometry and hydrogen-deuterium exchange mass spectrometry to elucidate the metal-mediated assembly pathway of EncFtn.

