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Interactions Among Regulatory Non-coding RNAs Involved in Cardiovascular Diseases
André F Gabriel1,2, Marina C Costa1,2, Francisco J Enguita3,4
1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Advances in Experimental Medicine and Biology
|April 15, 2020
Summary
Non-coding RNAs regulate gene expression and are implicated in cardiovascular diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) interact with microRNAs (miRNAs), influencing disease development.
Area of Science:
- Molecular Biology
- Genetics
- Cardiovascular Research
Background:
- Non-coding RNAs (ncRNAs) are crucial regulators of gene expression in human cells.
- ncRNAs play roles in various cellular processes and are implicated in cardiovascular diseases.
- Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) can function as competing endogenous RNAs (ceRNAs).
Purpose of the Study:
- To summarize the regulatory relationships among lncRNAs, circRNAs, and microRNAs (miRNAs).
- To highlight the role of these ncRNA interactions in the pathophysiology of cardiovascular diseases.
Main Methods:
- Review and summarization of existing literature on ncRNA interactions.
- Analysis of the regulatory mechanisms involving lncRNAs, circRNAs, and miRNAs in cardiovascular disease.
Main Results:
- lncRNAs, circRNAs, and miRNAs form complex regulatory networks.
- These interactions, acting as ceRNAs, influence gene expression and cellular functions.
- Evidence suggests a significant role for ncRNA crosstalk in cardiovascular disease development.
Conclusions:
- The intricate crosstalk between lncRNAs, circRNAs, and miRNAs is a key factor in cardiovascular disease.
- Understanding these regulatory networks offers insights into disease mechanisms and potential therapeutic targets.
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