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Author Spotlight: Nuclei Isolation from Mouse Cardiac Progenitor Cells for Epigenome and Gene Expression Profiling at Single-Cell Resolution
Published on: May 12, 2023
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Comprehensive Overview of Non-coding RNAs in Cardiac Development
Enrico Pozzo1, Yoke Chin Chai1, Maurilio Sampaolesi2,3
1Translational Cardiomyology Laboratory, Stem Cell Research Institute, Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Advances in Experimental Medicine and Biology
|April 15, 2020
Summary
Non-coding RNAs (ncRNAs) are crucial for human heart development. This review details how microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) orchestrate key cardiac organogenesis phases.
Area of Science:
- Developmental Biology
- Molecular Biology
- Genetics
Background:
- Human cardiac development involves complex interactions of transcription and growth factors.
- Cardiogenesis relies on coordinated cell proliferation, differentiation, fate specification, and morphogenesis.
- Non-coding RNAs (ncRNAs) are emerging as key regulators in cellular signaling and development.
Purpose of the Study:
- To summarize the current understanding of ncRNAs in cardiac organogenesis.
- To highlight the roles of microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) in heart formation.
- To provide an overview of ncRNA involvement across the four sequential phases of cardiac development.
Main Methods:
- Literature review of recent research on ncRNAs and cardiogenesis.
- Analysis of studies focusing on miRNAs, lncRNAs, and circRNAs.
- Synthesis of findings related to ncRNA functions in distinct stages of heart development.
Main Results:
- ncRNAs play significant roles in regulating gene expression during cardiac development.
- Specific miRNAs, lncRNAs, and circRNAs are implicated in controlling cell proliferation, differentiation, and morphogenesis.
- These ncRNAs act as crucial inter- and intra-cellular modulators in heart formation.
Conclusions:
- ncRNAs are essential orchestrators of human cardiac organogenesis.
- Understanding the functions of miRNAs, lncRNAs, and circRNAs provides insights into normal heart development.
- Further research into ncRNAs may reveal therapeutic targets for congenital heart diseases.
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