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Frailty Assessment in an Aging Mouse Model
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Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors
Mohamad Syahrir Azizi1, Sally Aman Nasution, Siti Setiati
1Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. dr.syahrirazizi@yahoo.com.
Acta Medica Indonesiana
|April 16, 2020
Summary
In elderly patients, frailty and diabetes mellitus significantly decrease global longitudinal strain (GLS), a key indicator of heart health. Early detection of reduced GLS can improve cardiovascular disease outcomes.
Area of Science:
- Cardiology
- Geriatrics
- Echocardiography
Background:
- Cardiovascular disease (CVD) is a leading cause of mortality in the elderly.
- Subclinical left ventricular systolic dysfunction (LVSD) often precedes symptomatic CVD.
- Early detection of LVSD is crucial for reducing morbidity and mortality.
Purpose of the Study:
- To determine the mean global longitudinal strain (GLS) in elderly patients.
- To identify factors associated with decreased GLS in this population.
Main Methods:
- Cross-sectional study of 194 patients aged >60 years.
- Data collected via interviews, medical records, and transthoracic echocardiography.
- Analysis of age, frailty, hypertension, coronary artery disease, dyslipidemia, and diabetes mellitus as determinants of GLS.
Main Results:
- The mean GLS was -21.6%.
- Frailty (OR 2.002) and diabetes mellitus (OR 2.278) were identified as significant determinants of decreased GLS.
- Hypertension and dyslipidemia were also associated with decreased GLS (p<0.25).
Conclusions:
- Frailty and diabetes mellitus are key factors influencing reduced GLS in the elderly.
- Mean GLS in this cohort was -21.6%.
- Findings highlight the importance of assessing GLS for early CVD risk identification in older adults.
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