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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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B Cell Lymphoma.

Xin Meng1, Qing Min1, Ji-Yang Wang2

  • 1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Advances in Experimental Medicine and Biology
|April 24, 2020
PubMed
Summary
This summary is machine-generated.

Genetic alterations during B cell development can lead to B cell lymphomas, which account for 95% of lymphomas. This chapter reviews common B cell lymphomas, including their features and genetic causes.

Keywords:
B cell non-Hodgkin lymphomaB lymphoblastic leukemia/lymphomaChromosomal translocationHodgkin lymphomaMolecular target therapy

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Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • B cell development involves genetic alterations like V(D)J recombination and somatic hypermutation.
  • Aberrant genetic events in B cells can lead to chromosomal translocations and mutations.
  • These genetic changes disrupt B cell survival and proliferation, driving lymphomagenesis.

Purpose of the Study:

  • To summarize the key aspects of prevalent B cell lymphomas.
  • To provide an overview of their morphology, immunophenotypes, and clinical features.
  • To detail the genetic defects, treatments, and prognosis associated with these malignancies.

Main Methods:

  • Review of scientific literature on B cell lymphomas.
  • Synthesis of information regarding genetic alterations, clinical presentations, and therapeutic strategies.
  • Categorization of lymphomas into precursor and mature B cell types.

Main Results:

  • B cell lymphomas represent 95% of all lymphoma cases.
  • Common B cell lymphomas include B-cell acute lymphoblastic leukemia/lymphoma (B-ALL/LBL), Hodgkin lymphoma, and B-cell non-Hodgkin lymphoma.
  • Genetic defects are crucial in the pathogenesis and classification of these cancers.

Conclusions:

  • Understanding the genetic underpinnings of B cell lymphomas is critical for diagnosis and treatment.
  • Comprehensive knowledge of lymphoma subtypes, including their genetic defects, aids in predicting prognosis and guiding therapy.
  • This chapter serves as a resource for the morphology, immunophenotypes, clinical features, genetic defects, treatments, and prognosis of major B cell lymphomas.