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B Cell Lymphoma

Xin Meng1, Qing Min1, Ji-Yang Wang2

  • 1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Advances in Experimental Medicine and Biology
|April 24, 2020
PubMed

B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B cell survival or proliferation and consequently B lymphomagenesis. In fact, B cell lymphoma accounts for 95% of the lymphomas. In this chapter, we summarize the morphology, immunophenotypes, clinical features, genetic defects that cause the malignancies, treatments, and prognosis of the most prevalent types of B cell lymphomas, including typical precursor B cell malignance (B-ALL/LBL) and mature B cell lymphoma (Hodgkin lymphoma and B cell non-Hodgkin lymphoma).

Keywords:
B cell non-Hodgkin lymphomaB lymphoblastic leukemia/lymphomaChromosomal translocationHodgkin lymphomaMolecular target therapy

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