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Updated: Dec 20, 2025
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High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
Published on: November 28, 2016
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Viruses in Bovine Respiratory Disease in North America: Knowledge Advances Using Genomic Testing
1Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA.
Summary
Advances in viral sequencing have identified new viruses linked to bovine respiratory disease (BRD) in cattle. Further research is needed to confirm their role in disease and explore potential vaccines for control.
Area of Science:
- Veterinary Virology
- Animal Infectious Diseases
- Bovine Respiratory Disease (BRD) Research
Background:
- Bovine respiratory disease (BRD) is a significant concern in cattle production.
- Traditional diagnostic methods have limitations in identifying all causative agents.
- Recent advancements in viral sequencing have opened new avenues for pathogen discovery.
Purpose of the Study:
- To highlight recent advances in viral detection for BRD.
- To identify novel viruses associated with respiratory illness in cattle.
- To assess the prevalence and potential pathogenicity of newly identified viruses.
Main Methods:
- Utilized advanced viral sequencing techniques on respiratory tract samples from cattle.
- Conducted serosurveys to determine the prevalence of detected viruses in North American cattle populations.
- Performed animal challenge studies to evaluate the disease-causing potential of identified viruses.
Main Results:
- Identified several novel viruses, including influenza D virus, bovine coronavirus, bovine rhinitis A, and bovine rhinitis B virus.
- Serosurveys confirmed the widespread presence of some of these viruses in cattle.
- Some viruses were found more frequently in BRD cases than in healthy cattle and demonstrated pathogenicity in challenge studies.
Conclusions:
- Viral sequencing has significantly improved the detection of pathogens associated with BRD.
- Newly identified viruses are prevalent and may contribute to BRD, necessitating further investigation.
- Development of specific reagents and vaccines is crucial for effective control strategies against these emerging viral threats.
Keywords:
BioinformaticsBovine coronavirusesBovine herpesvirus 1Bovine viral diarrhea virusesCattleGenetic sequencingInfluenza D virusMore Related Videos
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