Point-wise correlations between 10-2 Humphrey visual field and OCT data in open angle glaucoma

Area of Science:

• Ophthalmology
• Medical Imaging
• Neuroscience

Background:

• Glaucoma diagnosis and monitoring rely on assessing visual field (VF) loss and retinal structural changes.
• Optical Coherence Tomography (OCT) provides detailed cross-sectional imaging of the retina.
• Spectral Domain OCT (SD-OCT) offers high-resolution retinal imaging for clinical use.

Purpose of the Study:

• To map the relationships between visual field sensitivities and retinal structural measures obtained from SD-OCT.
• To investigate the correlation between specific retinal layers and peripapillary retinal nerve fiber layer (RNFL) thickness with VF sensitivities.
• To evaluate the predictive capability of OCT data for glaucoma staging.

Main Methods:

• Retrospective analysis of 63 eyes from open-angle glaucoma patients.
• Measurement of retinal thickness for the full retina, outer retina, ganglion cell complex, and peripapillary RNFL using SD-OCT.
• Correlation analysis between OCT measures (including RNFL sectors) and Humphrey 10-2/24-2 visual field sensitivities.
• Fitting OCT data to VF data to predict glaucoma stage.

Main Results:

• Retinal thickness and visual sensitivity correlations align with known retinal topography.
• Spatial correlation patterns between VF sensitivities and RNFL thickness broadly support existing structure-function maps, indicating a need for refinement.
• OCT data demonstrated predictive capability for glaucoma stage.

Conclusions:

• Ganglion cell complex thickness is a promising metric for glaucoma detection and monitoring.
• Retinal nerve fiber layer (RNFL) thickness measurements are valuable for glaucoma assessment.
• OCT-derived structural metrics show significant potential for enhancing glaucoma management.