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What about COVID-19 and arachidonic acid pathway?
1Department of Chemical-Toxicological and Pharmacological Evaluations of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana, Albania. m.hoxha@unizkm.al.
European Journal of Clinical Pharmacology
|June 26, 2020
Summary
Arachidonic acid (AA) may protect against COVID-19, while its deficiency increases susceptibility. Targeting inflammatory mediators like prostaglandins (PGs) could reduce COVID-19 severity.
Area of Science:
- Biochemistry
- Immunology
- Virology
Background:
- COVID-19 is a contagious viral disease with complex pathophysiology.
- The arachidonic acid (AA) pathway's role in COVID-19 remains incompletely understood.
Purpose of the Study:
- To define and discuss the association between the arachidonic acid (AA) pathway and COVID-19 pathophysiology.
- To explore the potential of targeting AA pathway mediators for COVID-19 treatment.
Main Methods:
- Comprehensive literature search across major scientific databases (PubMed, Scopus, Embase, Cochrane).
- Systematic review and analysis of 25 identified studies.
Main Results:
- Prostaglandins (PGs), particularly PGE2, exhibit pro-inflammatory effects in COVID-19.
- Arachidonic acid (AA) functions as an endogenous antiviral compound.
- AA deficiency is linked to increased COVID-19 susceptibility.
Conclusions:
- Measuring PGE2 and other PG levels in COVID-19 patients is recommended.
- Inhibiting human microsomal prostaglandin E synthase-1 (mPGES-1) may enhance immune response.
- Novel therapeutics, such as COX-2 inhibitors/TP antagonists, show promise for managing AA mediators in COVID-19.
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