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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Non-FDG PET/CT.

Egesta Lopci1, Stefano Fanti2

  • 1Nuclear Medicine Department, Humanitas Clinical and Research Hospital-IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italy. egesta.lopci@gmail.com.

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This review explores novel positron emission tomography (PET) tracers beyond 18F-FDG for cancer imaging. It details their clinical impact and potential in diagnosing various cancer hallmarks.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Positron Emission Tomography (PET) is crucial in clinical cancer imaging.
  • 18F-FDG is the primary radiotracer in nuclear oncology.
  • Advances in understanding cancer biology have driven the development of new PET tracers.

Purpose of the Study:

  • To summarize selected non-18F-FDG PET tracers.
  • To describe their introduction and impact on clinical practice.
  • To highlight tracers targeting various cancer hallmarks.

Main Methods:

  • Literature review of non-18F-FDG PET tracers.
  • Analysis of clinical applications and diagnostic trial data.
  • Categorization based on cancer hallmarks and clinical utility.

Main Results:

  • Numerous novel PET tracers have been developed, targeting diverse cancer pathways.
  • Some non-18F-FDG tracers are in clinical routine, while others are under investigation.
  • These tracers offer significant potential for improved cancer diagnosis and management.

Conclusions:

  • Non-18F-FDG PET tracers represent a growing field in molecular imaging.
  • They complement 18F-FDG by targeting specific cancer features.
  • Continued research promises expanded clinical applications in oncology.