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Agreement Between Two Optical Biometers Based on Large Coherence Length SS-OCT and Scheimpflug Imaging/Partial
Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|July 10, 2020
Summary
A new optical biometer using swept-source optical coherence tomography (SS-OCT) shows excellent agreement with a Scheimpflug/partial coherence interferometry (PCI) device for most ocular measurements. The devices demonstrated high concordance in axial length, corneal thickness, and keratometry, vital for refractive surgery planning.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Medical Device Technology
Background:
- Accurate ocular biometry is crucial for refractive error correction and intraocular lens power calculation.
- Advancements in optical biometry aim to improve measurement precision and reliability.
- Comparing new technologies with established methods is essential for clinical adoption.
Purpose of the Study:
- To evaluate the agreement between a new swept-source optical coherence tomography (SS-OCT) biometer (Argos) and a Scheimpflug/partial coherence interferometry (PCI) biometer (Pentacam AXL).
- To assess the concordance of key ocular parameters including axial length, central corneal thickness (CCT), anterior chamber depth (ACD), keratometry, and corneal diameter.
Main Methods:
- Measurements were performed in triplicate by the same examiner on 145 adult subjects.
- Paired t tests and Bland-Altman analysis were used to compare measurements from the Argos and Pentacam AXL devices.
- Evaluated parameters included axial length, CCT, ACD, mean keratometry, J0 and J45 vectors, and corneal diameter.
Main Results:
- Excellent agreement was found between the two biometers for axial length (difference: -0.02 ± 0.05 mm), CCT (1.15 ± 5.79 µm), ACD (-0.04 ± 0.04 mm), mean keratometry (-0.28 ± 0.16 D), and astigmatism vectors (J0: 0.01 ± 0.11 D, J45: -0.02 ± 0.10 D).
- Corneal diameter showed poor agreement, with 95% limits of agreement ranging from -2.25 to 0.19 mm.
- Bland-Altman plots indicated narrow agreement ranges for most parameters, supporting high concordance.
Conclusions:
- The new SS-OCT optical biometer (Argos) demonstrates excellent agreement with the Scheimpflug/PCI biometer (Pentacam AXL) for critical ocular measurements.
- This high level of agreement suggests the Argos biometer is a reliable tool for clinical applications, particularly in refractive surgery.
- Discrepancies in corneal diameter measurements warrant further investigation.
