Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.5K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.5K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.6K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.6K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.6K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

366
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
366
Autophagic Cell Death01:18

Autophagic Cell Death

4.1K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.1K
Schizophrenia01:17

Schizophrenia

590
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
590

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lanthanide-tungstobismuthate clusters based on [BiW9O33]9- building units: synthesis, crystal structures, luminescent and magnetic properties.

Dalton transactions (Cambridge, England : 2003)·2012
Same author

Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD.

Cell·2012
Same author

Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment.

Water research·2012
Same author

A new technique for partial removal of the pulmonary artery in video-assisted thoracic surgical lobectomy.

The Journal of thoracic and cardiovascular surgery·2012
Same author

Tm:YLF laser-pumped periodically poled MgO-doped congruent LiNbO3 crystal optical parametric oscillators.

Optics letters·2012
Same author

[A depression model of social defeat etiology using tree shrews].

Dong wu xue yan jiu = Zoological research·2012
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Dec 14, 2025

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.0K

Autophagy and Schizophrenia.

Yuexiong Yang1, Lin Xu2

  • 1Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Center for Excellence in Brain Science and Intelligence Technology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.

Advances in Experimental Medicine and Biology
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Autophagy dysfunction is linked to schizophrenia (SCZ), impacting brain regions like BA22 and hippocampus. Antipsychotics may treat SCZ by modulating autophagy and dopamine receptors.

Keywords:
AutophagyBrodmann areaHippocampusSchizophrenia

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.3K
Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.8K

Related Experiment Videos

Last Updated: Dec 14, 2025

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.0K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.3K
Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.8K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Schizophrenia (SCZ) presents with altered thoughts, perceptions, and motivation, but its neuropathology is not fully understood.
  • Emerging research suggests a connection between autophagy, a cellular degradation process, and SCZ.
  • Autophagy-related genes (ATGs) expression in specific brain regions and mTOR pathway dysregulation offer potential links.

Purpose of the Study:

  • To explore the association between autophagy and the neuropathogenesis of schizophrenia.
  • To investigate the role of autophagy dysfunction in specific brain areas related to SCZ symptoms.
  • To examine the impact of antipsychotic medications on autophagy in the context of SCZ.

Main Methods:

  • Analysis of autophagy-related gene (ATG) expression in postmortem brain samples (BA22) from SCZ patients.
  • Review of brain imaging studies correlating with SCZ symptoms and autophagy hypotheses.
  • Examination of mTOR regulation of autophagy.
  • In vitro studies on antipsychotic-induced autophagy and dopamine receptor antagonism.

Main Results:

  • Elevated ATG expression in BA22 of SCZ patients supports the autophagy-SCZ link.
  • Hippocampal autophagy dysfunction, particularly in CA2, may underlie social deficits in SCZ.
  • mTOR pathway dysregulation provides further evidence for autophagic neuropathogenesis in SCZ.
  • Antipsychotics demonstrate autophagy-inducing properties via distinct mechanisms, potentially acting as dopamine receptor antagonists.

Conclusions:

  • Autophagy dysfunction is a significant factor in schizophrenia neuropathogenesis.
  • Targeting autophagy pathways presents a potential therapeutic strategy for SCZ.
  • Antipsychotic medications may exert therapeutic effects by modulating autophagy and dopamine signaling.