Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebrospinal Fluid01:21

Cerebrospinal Fluid

4.5K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
4.5K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.7K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis.

Blood·2025
Same author

Emapalumab as salvage therapy for adults with malignancy-associated hemophagocytic lymphohistiocytosis.

Haematologica·2024
Same author

Clonal-pattern Seborrheic Keratosis: Risk of Recurrence and Progression to Carcinoma.

The American journal of surgical pathology·2022
Same author

Reference Laboratory Testing for Neurologic Disorders.

Clinics in laboratory medicine·2020
Same author

Advances in Clinical Laboratory Testing for Neurologic Disorders.

Clinics in laboratory medicine·2020
Same author

Intralymphatic histiocytosis in healing cellulitis: Case report and review of the literature.

Journal of cutaneous pathology·2020
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: Dec 13, 2025

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

11.5K

Cerebrospinal Fluid Testing for Multiple Sclerosis.

Joshua F Goldsmith1, A Zara Herskovits1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

Clinics in Laboratory Medicine
|July 29, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system. This review covers current cerebrospinal fluid analysis for MS diagnostics and explores emerging laboratory techniques for improved detection.

Keywords:
Autoimmune diseaseBiomarkersCerebrospinal fluidIsoelectric focusingMultiple sclerosis

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.8K
A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

8.1K

Related Experiment Videos

Last Updated: Dec 13, 2025

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

11.5K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.8K
A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

8.1K

Area of Science:

  • Neurology
  • Immunology
  • Clinical Diagnostics

Background:

  • Multiple sclerosis (MS) is a prevalent autoimmune disorder impacting the central nervous system.
  • Current diagnostic standards for MS rely on clinical evaluation, neuroimaging, and analysis of bodily fluids.
  • Cerebrospinal fluid (CSF) analysis is a key component in the diagnostic workup of suspected MS.

Purpose of the Study:

  • To review the established laboratory methods for cerebrospinal fluid analysis in the context of multiple sclerosis.
  • To discuss novel and emerging analytical approaches for enhancing the diagnostic accuracy of MS.
  • To provide an overview of the evolving landscape of MS diagnostics through CSF examination.

Main Methods:

  • Review of current literature on cerebrospinal fluid analysis techniques for multiple sclerosis.
  • Description of standard laboratory procedures for CSF examination.
  • Exploration of recent advancements and future directions in MS diagnostic markers within CSF.

Main Results:

  • Established methods for CSF analysis in MS include oligoclonal band detection and immunoglobulin G (IgG) index.
  • Newer techniques focus on identifying specific biomarkers and utilizing advanced analytical platforms.
  • These emerging approaches aim to improve sensitivity and specificity in MS diagnosis.

Conclusions:

  • Cerebrospinal fluid analysis remains a critical tool in diagnosing multiple sclerosis.
  • Advancements in laboratory diagnostics offer potential for earlier and more accurate MS detection.
  • Continued research into CSF biomarkers will refine diagnostic strategies for central nervous system autoimmune diseases.