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Evidence for modulation of EEG microstate sequence by vigilance level
Marina Krylova1, Sarah Alizadeh2, Igor Izyurov3
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany.
Neuroimage
|September 24, 2020
Summary
Brain electric field configurations, or EEG microstates, are linked to vigilance. Higher vigilance correlates with microstate C, while lower vigilance links to microstates A and B, impacting cognitive research.
Area of Science:
- Neuroscience
- Cognitive Science
- Brain Imaging
Background:
- Brain's global functional state is reflected in electric field configurations, identified as EEG microstates (A-D).
- Microstate parameter changes are relevant to cognition, neuropsychiatric disorders, and mental states.
- Assessing microstate dynamics using eye-closed resting-state data may introduce vigilance-related confounds.
Purpose of the Study:
- To investigate the association between EEG microstate parameters and vigilance levels.
- To determine if vigilance influences microstate dynamics.
Main Methods:
- Analysis of two independent datasets examining EEG microstate parameters.
- Vigilance level assessment using EEG power analysis and fMRI global signal.
- Granger-causality analysis to explore causal relationships between vigilance and microstate sequences.
Main Results:
- EEG microstate parameters are significantly associated with vigilance levels.
- Microstate C duration, contribution, and transitions are positively correlated with vigilance.
- Microstates A and B show an inverse relationship with vigilance.
- Vigilance levels exhibit Granger-causal effects on microstate sequence parameters.
Conclusions:
- Vigilance level is a critical confound in resting-state EEG microstate analysis.
- Duration and occurrence of microstates may stem from different physiological processes.
- Future resting-state EEG studies must account for vigilance levels to ensure accurate interpretation of microstate dynamics.
