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Neuregulin Signaling in the Tumor Microenvironment

Ruxue Jia1,2, Hu Zhao1,2, Shuiliang Wang3,4

  • 1Fujian Provincial Key Laboratory of Transplant Biology, Affiliated Dongfang Hospital, Xiamen University School of Medicine, Fuzhou, Fujian Province, China.

Advances in Experimental Medicine and Biology
|October 30, 2020
PubMed
Summary

Neuregulin signaling, crucial for normal cell functions, drives cancer initiation, metastasis, and therapeutic resistance by interacting with the tumor microenvironment. Targeting this pathway offers a potential therapeutic strategy for various human cancers.

Keywords:
Development of cancerEpigeneticsEpithelial–mesenchymal transition (EMT)ErbB familyGeneticsMetastasisNeuregulins (NRGs)/heregulins (HRGs)ParacrineReceptor tyrosine kinases (RTKs)Signaling pathwayTarget therapyTherapeutic resistanceTumor biologyTumor microenvironment (TME)Tumorigenesis

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