Related Experiment Video
Updated: Nov 29, 2025
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
Use of Intraoperative Fluorophores
Alexander J Schupper1, Constantinos Hadjipanayis2
1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY, USA.
Abstract:
Fluorescence-guided surgery provides surgeons with improved visualization of tumor tissue in the operating room to allow for maximal safe resection of brain tumors. Multiple fluorescent agents have been studied for fluorescence-guided surgery. Both nontargeted and targeted fluorescent agents are currently being used for glioblastoma multiforme visualization and resection. Fluorescence detection in the visible light or near infrared spectrum is possible. Visualization device advancements have permitted greater detection of fluorescence down to the cellular level, which may provide even greater ability for the neurosurgeon to resect tumors.
Insights
Fluorescence-guided surgery enhances brain tumor visualization for surgeons. Advancements in imaging and agents improve tumor resection, aiding neurosurgeons in achieving maximal safe removal.
Area of Science:
- Neurosurgery
- Medical Imaging
- Oncology
Background:
- Fluorescence-guided surgery (FGS) improves intraoperative visualization of brain tumors.
- Accurate tumor resection is critical for patient outcomes in neuro-oncology.
- Current methods rely on various fluorescent agents and imaging technologies.
Purpose of the Study:
- To review the role of fluorescence-guided surgery in brain tumor resection.
- To discuss the advancements in fluorescent agents and visualization devices.
- To highlight the potential for improved maximal safe resection of gliomas.
Main Methods:
- Review of current literature on fluorescence-guided surgery for brain tumors.
- Analysis of different types of fluorescent agents (targeted and non-targeted).
- Discussion of fluorescence detection in visible and near-infrared spectra.
Main Results:
- Fluorescence-guided surgery offers enhanced visualization of tumor tissue.
- Both targeted and non-targeted fluorescent agents are utilized for glioblastoma.
- Advancements in visualization devices enable cellular-level fluorescence detection.
Conclusions:
- Fluorescence-guided surgery is a valuable tool for maximal safe resection of brain tumors.
- Ongoing technological advancements promise further improvements in surgical precision.
- Enhanced visualization aids neurosurgeons in differentiating tumor from healthy tissue.
