Comparison of computed tomography- and magnetic resonance imaging-based target delineation for cervical cancer...

The objective of this study was to compare and assess the accuracy of computed tomography (CT)-based target delineation with that of magnetic resonance imaging (MRI)-based on high-dose-rate brachytherapy (HDR-BT) for patients with cervical cancer.

Data of 20 patients with locally advanced cervical cancer were collected and evaluated. Dimensions, conformity, and dose parameters of high-risk clinical target volume (CTV_HR) as well as D_0.1cc, D_1cc, and D_2cc of organs at risk (OARs) based on MRI were compared with those based on CT.

Average age of 20 patients included was 57.8 years. Width, thickness, and volumes of CT-based CTV_HR (CTV_HR-CT) were significantly overestimated compared with those of MRI-based CTV_HR (CTV_HR-MR). Mean values of dice similarity coefficient (DSC), Hausdorff distance (HD), and centroid distance (ΔV) of CTV_HR were 0.82 cm, 0.96 cm, and 0.35 cm, respectively. Dose values of CTV_HR-CT were significantly lower compared with those of CTV_HR-MR. Concerning OARs, geometrical and dosimetric values on CT were comparable to those on MRI.

The delineated ranges of CTV_HR were significantly over-estimated on CT compared with MRI. D₉₈ and D₉₀ of CTV_HR-CT were lower than CTV_HR-MR. DSC and ΔV of CTV_HR and CTV_IR were similar to each other; however, there was a difference in terms of HD. CT images regarding pre-BT MR images for delineating were not enough and MRI fusion is still required.