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[3 + 2] Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles

Liang Tu1, Limei Gao1, Xiaomeng Wang1

  • 1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.

The Journal of Organic Chemistry
|December 10, 2020
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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