Related Experiment Video
Updated: Nov 19, 2025

11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.3K
[Switching from atopic dermatitis to psoriasis - and back].
Wolf-Henning Boehncke1, Romaine Stalder2, Nicolò Costantino Brembilla2
1Service de dermatologie et vénéréologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
Revue Medicale Suisse
|January 28, 2021
Summary
Atopic dermatitis and psoriasis are distinct skin conditions. Therapies targeting one disease can sometimes trigger the other, offering new insights into their pathophysiology and treatment.
Area of Science:
- Dermatology
- Immunology
- Pathophysiology
Background:
- Atopic dermatitis and psoriasis are clinically and pathogenetically distinct inflammatory skin diseases.
- Targeted therapies have advanced treatment by inhibiting key pathogenic pathways.
Purpose of the Study:
- To explore the interplay between atopic dermatitis and psoriasis.
- To understand how therapies for one condition can influence the other.
Main Methods:
- Observational analysis of treatment-induced disease onset.
- Review of clinical and pathogenetic data.
Main Results:
- Specific therapies for atopic dermatitis or psoriasis can occasionally induce the onset of the other condition.
- This phenomenon highlights shared or interconnected pathogenic mechanisms.
Conclusions:
- The cross-induction of atopic dermatitis and psoriasis suggests a more complex relationship than previously understood.
- These findings have implications for the management and therapeutic strategies for both inflammatory skin diseases.
Related Concept Videos
Skin Diseases and Disorders
4.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.7K
T Cell Types and Functions
1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K
Renewal of Skin Epidermal Stem Cells
2.8K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.8K
Hypersensitivities
4.4K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
4.4K
Allergic Drug Reactions
1.2K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.2K
Clinical Applications of Epidermal Stem Cells
3.0K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.0K

