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IL-23 and the Tumor Microenvironment.

Sweta Subhadarshani, Nabiha Yusuf, Craig A Elmets1

  • 1Department of Dermatology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, University Boulevard, Birmingham, AL, USA. celmets@uabmc.edu.

Advances in Experimental Medicine and Biology
|February 9, 2021
PubMed
Summary
This summary is machine-generated.

Interleukin-23 (IL-23) plays a complex role in cancer, influencing tumor growth and immune response. Further research into IL-23 pathways may reveal new cancer treatment targets.

Keywords:
AngiogenesisBreast cancerColorectal cancerEsophageal cancerInterleukinsMatrix metallopeptidasesMelanocytic neviMelanomaMultiple myelomaNonmelanoma skin cancerPediatric B-acute lymphocytic leukemiaPericytesPsoriasis therapyTumor microenvironmentTumor-associated macrophages

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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • The tumor microenvironment (TME) is crucial for cancer development, progression, and metastasis.
  • Cytokines within the TME, like interleukin-23 (IL-23), significantly impact malignant transformation.
  • Understanding the cytokine milieu is critical for deciphering cancer biology.

Purpose of the Study:

  • To investigate the multifaceted role of interleukin-23 (IL-23) in cancer.
  • To explore how IL-23 modulates host immune responses and tumor cells within the TME.
  • To examine the downstream signaling pathways of IL-23, including JAK/STAT signaling.

Main Methods:

  • Review of existing literature on IL-23 in cancer research.
  • Analysis of IL-23's interaction with its receptor (IL-12Rβ1 and IL-23R).
  • Examination of IL-23's downstream signaling cascade involving janus kinase (JAK) and signal transducer and activator of transcription (STAT) 3/4.

Main Results:

  • IL-23 exhibits both pro- and anti-tumor effects, depending on context (genetics, tumor type, causative agent).
  • IL-23 signaling impacts STAT3 activation in both tumor cells and the TME.
  • Clinical trials of IL-12/23 inhibitors for psoriasis have shown associations with nonmelanoma skin cancers (NMSCs).

Conclusions:

  • The role of IL-23 in cancer is complex and context-dependent.
  • IL-23 signaling pathways represent potential therapeutic targets for cancer management.
  • Further investigation is warranted to fully elucidate IL-23's impact on cancer and other diseases.