TOTAL ANTIOXIDANT ACTIVITY AND MANGANESE SUPEROXIDE DISMUTASE IN COMORBIDITY OF GASTROESOPHAGEAL REFLUX DISEASE AND...

Area of Science:

• Biochemistry
• Internal Medicine
• Gastroenterology
• Endocrinology

Background:

• Gastroesophageal reflux disease (GERD) and autoimmune thyroiditis (AIT) are common conditions.
• Comorbidity of GERD and AIT can significantly impact patient health and disease presentation.
• Understanding the biochemical markers in comorbid conditions is crucial for effective management.

Purpose of the Study:

• To investigate the total antioxidant activity and manganese superoxide dismutase levels in students with comorbid GERD and AIT.
• To compare these markers between patients with comorbid GERD and AIT versus those with isolated GERD or AIT.
• To assess the clinical characteristics associated with GERD and AIT comorbidity in a student population.

Main Methods:

• A study involving 120 students with GERD and AIT, 45 with GERD, and 42 with AIT.
• Utilized the international standardized GerdQ questionnaire to assess GERD symptoms.
• Measured total antioxidant activity and manganese superoxide dismutase levels in all participants.

Main Results:

• Comorbidity of GERD and AIT significantly increased heartburn frequency, sleep disturbances, and medication use.
• Patients with comorbid GERD and AIT showed significantly lower total antioxidant activity compared to those with isolated GERD or AIT.
• Manganese superoxide dismutase levels were significantly higher in the comorbid group than in the isolated disease groups.

Conclusions:

• Concomitant AIT in students with GERD alters clinical presentation, reduces total antioxidant activity, and activates manganese superoxide dismutase.
• The findings highlight a distinct biochemical profile in students with GERD and AIT comorbidity.
• Further research may explore therapeutic strategies targeting antioxidant pathways and specific enzymes in this patient group.