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Related Experiment Video

Updated: Nov 17, 2025

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

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OPTN/SRTR 2019 Annual Data Report: Intestine.

S P Horslen1,2, J M Smith2, Y Ahn1

  • 1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|February 17, 2021
PubMed
Summary
This summary is machine-generated.

Fewer intestine transplants are being performed due to medical advances. While graft failure has plateaued, early graft loss has increased recently, particularly in combined liver-intestine transplants.

Keywords:
Intestinal failureintestine transplantintestine-liver transplantwaiting list

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Area of Science:

  • Transplantation Medicine
  • Gastroenterology
  • Surgical Innovation

Background:

  • Intestine transplantation offers life-saving benefits for patients with intestinal failure.
  • Advances in medical and surgical treatments for intestinal failure have reduced the number of patients requiring transplantation.
  • This has led to a decrease in both waiting list additions and the number of performed intestine transplants.

Purpose of the Study:

  • To analyze recent trends in intestine transplantation, including patient listings, performed procedures, and transplant program activity.
  • To evaluate graft failure rates and patient survival following intestine transplantation.
  • To identify any changes in early graft loss, particularly in combined liver-intestine transplants.

Main Methods:

  • Retrospective analysis of national transplant data.
  • Examination of trends in patient listings and performed intestine transplants from 2010 to 2019.
  • Analysis of graft failure and patient survival rates for various intestine transplant types.

Main Results:

  • The number of intestine transplant listings and performed transplants reached a decade low in 2019.
  • The number of active transplant programs also hit a ten-year low in 2019.
  • While overall graft failure has plateaued, early graft loss has risen in the last two years, especially for combined liver-intestine allografts.
  • Five-year patient survival rates for transplants performed between 2012-2014 were consistent across different graft types.

Conclusions:

  • Despite the life-saving potential of intestine transplantation, the field is experiencing a decline in activity.
  • An emerging concern is the increase in early graft loss, particularly in combined liver-intestine transplants.
  • Continued monitoring and research are necessary to address these trends and improve long-term outcomes.