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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Whole-brain quantitative CEST MRI at 7T using parallel transmission methods and correction.

Andrzej Liebert1, Katharina Tkotz1, Jürgen Herrler2

  • 1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Magnetic Resonance in Medicine
|February 26, 2021
PubMed
Summary
This summary is machine-generated.

Quantitative CEST MRI at ultra-high magnetic fields is now faster and more accurate. The new MIMOSA FOCUS method with B1 correction significantly improves whole-brain imaging, reducing acquisition times for better clinical applications.

Keywords:
7Tchemical exchange saturation transferfast-online customized pulsesmultiple interleaved mode saturationparallel transmissionspiral non-selective trajectory

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Quantitative Imaging

Background:

  • Chemical Exchange Saturation Transfer (CEST) MRI is a powerful technique for quantitative imaging.
  • Ultra-high magnetic field strengths (≥7T) offer improved signal-to-noise ratio but present challenges for whole-brain coverage and speed.
  • Optimizing CEST MRI protocols is crucial for clinical translation.

Purpose of the Study:

  • To develop and validate a method for whole-brain quantitative CEST MRI at ultra-high magnetic field strengths (≥7T) within reduced acquisition times.
  • To assess the effectiveness of Multiple Interleaved Mode Saturation (MIMOSA) combined with fast online-customized (FOCUS) parallel transmission (pTx) excitation pulses and B1 correction.

Main Methods:

  • A novel MIMOSA FOCUS sequence with B1 correction was implemented and tested on a 7T MRI system.
  • Three pulse sequences were compared: CP mode, MIMOSA with CP readout, and MIMOSA with FOCUS readout.
  • Inter-subject coefficient of variation and time-point repeatability were evaluated in 13 volunteers.

Main Results:

  • The MIMOSA FOCUS sequence with B1 correction significantly reduced inhomogeneity in CEST contrasts, particularly in the occipital lobe and cerebellum.
  • This sequence demonstrated the most stable inter-subject coefficient of variation.
  • Time-point repeatability with single-point B1 correction showed a maximum coefficient of variation below 8%.

Conclusions:

  • The combination of MIMOSA FOCUS and single-point B1 correction enables quantitative CEST measurements at ultra-high magnetic fields.
  • This approach reduces overall acquisition time by eliminating the need for additional B1 correction scans.
  • The method offers a promising advancement for efficient and accurate whole-brain CEST MRI.