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Updated: Nov 12, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer
Fatemeh Forouzanfar1,2, Muhammed Majeed3, Tannaz Jamialahmadi4,5
1Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Telomerases are attractive targets for development of new anticancer agents. Most tumors express the enzyme telomerase that maintains telomere length and thus ensures indefinite cell proliferation, a hallmark of cancer. Curcumin has been shown to be effective against several types of malignancies and has also been shown to have inhibitory effects on telomerase activity. Hence, the aim of this chapter is to review the available investigations of curcumin on telomerase activity. Based on the findings obtained from the different studies here, we conclude that the telomerase inhibitory effects of curcumin are integral to its anticancer activity, and thus curcumin may be useful therapeutically in the cancer field.
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