Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative PANoptosis-focused omics analysis uncovers GSDMC as a candidate biomarker in breast cancer.

Frontiers in cell and developmental biology·2026
Same author

Baseline patient-reported symptom networks and early risk stratification for six-month symptom burden in newly diagnosed glioma: a prospective cohort study.

Frontiers in public health·2026
Same author

Preparation and characterization of physical crosslinked nanochitin/urea hydrogels via heat treatment for agricultural applications.

International journal of biological macromolecules·2026
Same author

<i>In situ</i> biomimetic near-infrared fluorescent protein formed by tumor signature proteins for detecting breast cancer biopsy.

Materials today. Bio·2026
Same author

Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory.

Phytotherapy research : PTR·2026
Same author

Feasibility of ontology-guided structuring of stress information from narrative text: An exploratory study using large language models.

Digital health·2026
Same journal

Compact, scan-pattern-switchable 2D piezoelectric MEMS mirror with 1D addressable scanning.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2026
Same journal

Fabrication of LCE Microactuator Arrays Through Soft Lithography with Surface Alignment.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2025
Same journal

An integrated, optofluidic system with aligned optical waveguides, microlenses, and coupling prisms for fluorescence sensing.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2024
Same journal

Gold Nanorod-Embedded PDMS Micro-Pillar Array for Localized Photothermal Stimulation.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2024
Same journal

Fabrication of Out-of-Plane High Channel Density Microelectrode Neural Array with 3D Recording and Stimulation Capabilities.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2024
Same journal

Microgaskets for High-Channel-Density Reconnectable Implantable Packaging.

Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems·2022
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.0K

A 512-Channel Multi-Layer Polymer-Based Neural Probe Array.

Kee Scholten1, Christopher E Larson1, Huijing Xu1

  • 1Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.

Journal of Microelectromechanical Systems : a Joint IEEE and ASME Publication on Microstructures, Microactuators, Microsensors, and Microsystems
|March 22, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a high-density polymer microelectrode array for large-scale brain recordings in rats. This new device significantly advances neural recording capabilities for neuroscience research.

Keywords:
Microelectrode arrayParylenebioMEMSbrain machine interfacesneural probe

More Related Videos

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

4.0K
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

35.1K

Related Experiment Videos

Last Updated: Nov 12, 2025

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

11.0K
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

4.0K
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

35.1K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Chronic, large-scale neural recording is crucial for understanding brain function.
  • Existing microelectrode arrays face limitations in electrode density and chronic stability.
  • Polymer-based microelectrodes offer potential for improved biocompatibility and flexibility.

Purpose of the Study:

  • To design, fabricate, and characterize a novel high-density, polymer-based penetrating microelectrode array.
  • To enable chronic, large-scale neural recordings in the cortices and hippocampi of behaving rats.
  • To advance polymer micro-machining techniques for neural probe fabrication.

Main Methods:

  • Development of two architectures with 512 Platinum recording electrodes each.
  • Utilizing thin-film Parylene C for micromachined eight-shank arrays.
  • Implementing advances in lithographic resolution and back-side electrode patterning.
  • Performing in vitro electrochemical characterization to verify electrode function.

Main Results:

  • Successful design and fabrication of a high-density, polymer-based penetrating microelectrode array.
  • Achieved an order of magnitude improvement in electrode number and density compared to previous polymer arrays.
  • Demonstrated suitable electrode function and surface properties through in vitro electrochemical testing.
  • Established novel polymer micro-machining methods for enhanced probe fabrication.

Conclusions:

  • The developed microelectrode array represents a significant advancement for chronic, large-scale neural recording.
  • The fabrication techniques pave the way for next-generation neural interfaces.
  • Further implementation in free-moving animal models is planned for in vivo validation.