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Related Experiment Video

Updated: Jun 14, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
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Fabrication of Out-of-Plane High Channel Density Microelectrode Neural Array with 3D Recording and Stimulation

Md Mobashir Hasan Shandhi1, Sandeep Negi1

  • 1School of Electrical and Computer Engineering. University of Utah, Salt Lake City, UT, USA.

Journal of Microelectromechanical Systems : a Joint IEEE and ASME Publication on Microstructures, Microactuators, Microsensors, and Microsystems
|September 6, 2024
PubMed
Summary

The Utah Multisite Electrode Array (UMEA) offers improved neural recording and stimulation by featuring multiple active sites per shaft, unlike the traditional Utah Electrode Array (UEA). This next-generation device enhances channel density for better neuronal access and bidirectional neuroprostheses.

Keywords:
MicroelectrodesNeural ElectrodesShadow MaskUtah Electrode ArrayUtah Multisite Electrode Array

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • The Utah Electrode Array (UEA) is a standard for high-channel count neural electrodes in bidirectional neuroprostheses.
  • A key limitation of the UEA is its single active site located only at the tip of each shaft.
  • This limits the ability to record from or stimulate multiple neural layers simultaneously.

Purpose of the Study:

  • To introduce and demonstrate the Utah Multisite Electrode Array (UMEA) as a next-generation neural electrode.
  • To overcome the single-site limitation of conventional UEAs.
  • To enhance neural recording and stimulation capabilities for bidirectional neuroprostheses.

Main Methods:

  • Fabrication of the UMEA using 3D shadow mask patterning technology for batch production.
  • Development of a UMEA prototype with three active sites per shaft: one at the tip and two at different heights along the shaft.
  • In-vitro characterization of the electrochemical properties of the UMEA's shaft sites.

Main Results:

  • The UMEA successfully incorporates multiple active sites per shaft, significantly increasing channel density compared to the UEA.
  • In-vitro tests confirmed the electrochemical viability of the new shaft sites for bidirectional neuroprostheses.
  • The UMEA demonstrated potential for accessing a larger neuronal population and different cortical layers.

Conclusions:

  • The UMEA represents a significant advancement over traditional UEAs for neuroprosthetic applications.
  • The multi-site design enhances recording and stimulation capabilities without increasing neuronal damage risk.
  • UMEA technology holds promise for more sophisticated and effective neural interfaces.