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Updated: Jun 11, 2025

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Gold Nanorod-Embedded PDMS Micro-Pillar Array for Localized Photothermal Stimulation.

Nafis Mustakim1, Luis F Rodriguez Vera2, Jose Pacheco Pinto1

  • 1Department of Electrical Engineering, The City College of New York, New York, NY 10031 USA.

Journal of Microelectromechanical Systems : a Joint IEEE and ASME Publication on Microstructures, Microactuators, Microsensors, and Microsystems
|October 4, 2024
PubMed
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This study introduces an arrayed platform using gold nanorods (GNRs) embedded in PDMS micropillars for precise photothermal neural stimulation. This innovation enables localized heating for potential neuromodulation with high spatiotemporal resolution.

Area of Science:

  • Biomaterials Science
  • Neuroengineering
  • Nanotechnology

Background:

  • Gold nanorods (GNRs) offer biocompatibility and tunable photothermal properties for neural stimulation.
  • Current GNR applications for neural disorders are limited by random distribution, hindering large-scale applications.
  • Developing arrayed GNR platforms is crucial for precise, localized neural modulation.

Purpose of the Study:

  • To develop an arrayed photothermal stimulation platform using GNRs embedded in PDMS micropillars.
  • To enable precise localization of GNRs for targeted neural activation.
  • To investigate the potential for high spatiotemporal resolution in photothermal neuromodulation.

Main Methods:

  • Fabrication of a polydimethylsiloxane (PDMS) micropillar array platform.
Keywords:
PDMS micropillar arrayPhotothermal stimulationgold nanorodnear-infrared actuationsoft lithography

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  • Embedding GNRs at the tips of PDMS micropillars.
  • Characterization of spatiotemporal temperature changes using rhodamine B dye and near-infrared (NIR) light.

    • Main Results:

    • Demonstrated successful localization of GNRs in an arrayed pixel-like configuration.
    • Achieved optically modulated localized temperature changes within 4°C using NIR light.
    • Confirmed temperature variations suitable for neuromodulation.

    Conclusions:

    • The proposed PDMS micropillar platform with embedded GNRs offers a novel approach for arrayed photothermal neural stimulation.
    • This platform addresses limitations of random GNR distribution, enabling precise control over localized heating.
    • The technology holds potential for developing advanced neural interfaces with high spatiotemporal resolution for therapeutic applications.