Related Experiment Video
Updated: Nov 10, 2025
10:39
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
7.9K
Innate Lymphoid Cells in Airway Inflammation
1Division of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, NY, USA. pasham@amc.edu.
Advances in Experimental Medicine and Biology
|March 31, 2021
Summary
Innate lymphoid cells type 2 (ILC2s) drive T helper type 2 (Th2) inflammation in airway diseases like asthma. Targeting ILC2s offers a potential therapeutic strategy for these conditions.
Area of Science:
- Immunology
- Respiratory Medicine
Background:
- Airways are crucial interfaces for immune surveillance against pathogens.
- Innate lymphoid cells (ILCs) are emerging as key regulators of tissue homeostasis and inflammation.
- Type 2 innate lymphoid cells (ILC2s) are implicated in T helper type 2 (Th2) inflammatory responses.
Purpose of the Study:
- To elucidate the role of ILC2s in the pathogenesis of type 2 airway diseases.
- To explore ILC2s as potential therapeutic targets in allergic airway inflammation.
Main Methods:
- The study reviews existing evidence on ILC2 function in airway inflammation.
- Analysis focuses on the contribution of ILC2s to Th2-mediated pathology in asthma.
Main Results:
- ILC2s are elevated in type 2 human airway diseases, such as asthma.
- ILC2s produce Th2 cytokines (e.g., IL-4, IL-5, IL-13) that amplify eosinophilic inflammation.
- ILC2s contribute significantly to the induction and maintenance of allergic airway inflammation.
Conclusions:
- ILC2s are central players in type 2 airway diseases.
- Targeting ILC2 activators or inhibitory pathways presents a promising therapeutic avenue.
- Modulating ILC2s could impact both innate and adaptive immune responses in allergic diseases.
Related Concept Videos
01:18Lymphoid Cells and Tissues
2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
01:28Cells of the Innate Immune Response
7.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
7.6K
01:26Asthma-II: Pathophysiology and Classification
3.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.5K
01:23Cells of the Adaptive Immune Response
7.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.3K
01:15Secondary Lymphoid Organs
7.9K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.9K
01:24T Cell Types and Functions
1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K