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Updated: Nov 6, 2025
05:56
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
9.1K
Axial length targets for myopia control.
Paul Chamberlain1, Percy Lazon de la Jara1, Baskar Arumugam1
1CooperVision Inc., Pleasanton, USA.
Summary
Myopia control contact lenses slowed eye elongation in children to levels similar to normal eye growth in emmetropes. This suggests physiological eye growth may limit myopia control effectiveness.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Myopia Research
Background:
- Eye elongation occurs in both emmetropic and myopic children.
- Understanding normal eye growth is crucial for evaluating myopia control interventions.
Purpose of the Study:
- Compare axial elongation in untreated myopes, treated myopes, and emmetropes.
- Contextualize myopia progression within normal emmetropic eye growth.
- Assess potential limits of myopia control based on physiological eye growth.
Main Methods:
- Utilized data from a 3-year myopia control contact lens trial (MiSight® 1 day).
- Compared trial data with axial elongation data from the Orinda Longitudinal Study of Myopia (OLSM) and Singapore Cohort Study of the Risk Factors for Myopia (SCORM).
- Calculated annual axial elongation using published study equations and created virtual cohorts for comparison.
Main Results:
- Untreated myopes showed 3-year axial elongation (0.62 mm) comparable to OLSM (0.70 mm) and SCORM (0.65 mm) models.
- Emmetropic virtual cohorts exhibited 3-year elongation of 0.24 mm (OLSM/SCORM), similar to MiSight-treated myopes (0.30 mm).
Conclusions:
- Myopia control treatments brought axial elongation closer to that of emmetropes.
- Hypothesize that myopic elongation is superimposed on physiological emmetropic eye growth.
- Suggest myopia control may minimize pathological elongation while preserving physiological growth.
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