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Updated: Nov 6, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Programming cell communications with pH-responsive DNA nanodevices.

Junjun Hou¹, Shitai Zhu¹, Ziwei Zhao²

¹Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China and University of Chinese Academy of Sciences, Beijing, 100049, China.

Chemical Communications (Cambridge, England)

|May 6, 2021

Summary

This summary is machine-generated.

DNA nanoswitches on cell surfaces change structure with pH shifts, enabling cell-to-cell connections. This pH-triggered communication is promising for tumor microenvironment therapies.

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Area of Science:

Biotechnology
Molecular Biology
Nanotechnology

Background:

Cell-surface modifications are crucial for targeted therapies.
The tumor microenvironment presents unique challenges for drug delivery and cell communication.

Purpose of the Study:

To develop a pH-responsive DNA nanoswitch for cell communication.
To investigate the potential of this system for cell-based therapies in tumor microenvironments.

Main Methods:

Designing DNA nanoswitches with pH-sensitive structural transitions.
Immobilizing nanoswitches on cell surfaces.
Demonstrating pH-triggered cell-cell connection via complementary DNA strands.

Main Results:

DNA nanoswitches successfully switched from a three-chain to a double-chain structure in response to physiological pH changes.
Nanoswitches facilitated the connection of modified cells, demonstrating triggered cell communication.
The system showed potential for application in tumor microenvironments.

Conclusions:

pH-responsive DNA nanoswitches offer a novel mechanism for controlled cell communication.
This technology holds promise for advancing cell-based therapies, particularly within the tumor microenvironment.