Intraocular Pressure Variations After Intravitreal Injections Measured With an Implanted Suprachoroidal Telemetry...

Area of Science:

• Ophthalmology
• Biomedical Engineering

Background:

• Intravitreal injections (IVIs) are common treatments for various ocular conditions.
• Transient intraocular pressure (IOP) elevation is a known risk associated with IVIs.
• Monitoring continuous IOP fluctuations post-IVIs is crucial for patient management.

Observation:

• A suprachoroidal tonometry sensor was implanted in a patient with glaucoma and macular edema undergoing deep sclerectomy.
• Continuous IOP was monitored before and after serial IVIs over a 1-year period.
• The sensor enabled real-time tracking of IOP dynamics following each injection.

Findings:

• In the initial 7 months post-surgery, IVIs led to a transient reduction in IOP, attributed to subconjunctival leaks or increased filtration.
• From 7 months onward, IVIs caused significant IOP spikes, with one reaching 44.8 mm Hg, suggesting resolution of initial leakage mechanisms.
• IOP normalized within hours post-injection in both phases, but the pattern shifted from reduction to sharp increase.

Implications:

• The study highlights the dynamic and evolving nature of IOP response to IVIs after deep sclerectomy.
• Understanding these IOP fluctuations is vital for optimizing treatment strategies and preventing complications in patients with glaucoma and macular edema.
• Implantable IOP sensors offer valuable insights into the physiological responses to intravitreal therapies.