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Updated: Nov 4, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[Urinary stone disease - size isn't all that matters]
Martin H Umbehr1, Michael Müntener1
1Klinik für Urologie, Stadtspital Waid und Triemli, Zürich.
Urinary stone disease, common in industrialized nations, requires prompt diagnosis. CT scans are superior to ultrasound for assessing urinary stones, especially when infection is suspected.
Area of Science:
- Urology
- Nephrology
Background:
- Urinary stone disease affects 10-15% of individuals in industrialized countries.
- It manifests as renal stone disease (often asymptomatic) or ureteral stone disease (causing acute flank pain).
- Ureteral stone disease necessitates immediate diagnostic evaluation.
Purpose of the Study:
- To highlight the diagnostic accuracy of CT scans over ultrasound for urinary stone disease.
- To emphasize the critical importance of identifying concurrent urinary tract infections.
- To underscore the emergency management of infected and obstructed urinary tracts.
Main Methods:
- Review of diagnostic modalities for urinary stone disease.
- Emphasis on clinical presentation, medical history, vital signs, and laboratory tests.
- Comparison of CT scans and ultrasound in stone assessment.
Main Results:
- CT scans demonstrate superior accuracy in assessing urinary stone disease compared to ultrasound.
- Concurrent urinary tract infection significantly elevates the risk associated with ureteral stone disease.
- Prompt diagnosis and management are crucial for preventing severe complications like urosepsis.
Conclusions:
- Accurate diagnosis of urinary stone disease, particularly ureteral stones, is essential.
- CT imaging is the preferred modality for comprehensive stone evaluation.
- Urgent urinary tract drainage is critical in cases of infection and obstruction to prevent life-threatening outcomes.
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