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The Hematological Differential Diagnosis of Mediastinal Masses
Ahmed Aljudi1, Elizabeth Weinzierl1, Mohamed Elkhalifa1
1Department of Pathology, Children's Healthcare of Atlanta, 1405 Clifton Road Northeast, Tower One, First Floor, Atlanta, GA 30322, USA.
Abstract:
Mediastinal masses commonly present in children and may pose diagnostic challenges, particularly with limited sampling. This article aids the pathologist by reviewing the hematologic differential diagnosis of a pediatric mediastinal mass, along with ancillary testing useful for rendering the correct diagnosis. A review of the more common lymphomas is presented, including classic Hodgkin lymphoma, T-lymphoblastic leukemia/lymphoma, and primary mediastinal (thymic) large B-cell lymphoma, along with brief mentions of less common entities such as gray zone lymphoma and thymoma as well as non-neoplastic conditions such as benign cysts and infections.
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