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The blood-retinal barrier in Berlin's edema
1Department of Ophthalmology, University of Illinois College of Medicine, Chicago.
Retina (Philadelphia, Pa.)
|January 1, 1987
Summary
Berlin's edema pathogenesis is unclear, but blood-retinal barrier breakdown was investigated. Studies found no significant barrier disruption, suggesting "commotio retinae" is a more appropriate term pending further evidence.
Area of Science:
- Ophthalmology
- Retinal Diseases
Background:
- The exact cause of Berlin's edema remains uncertain.
- Breakdown of the blood-retinal barrier is a potential contributing factor.
Purpose of the Study:
- To evaluate the role of blood-retinal barrier integrity in Berlin's edema.
- To assess 10 patients with Berlin's edema using advanced imaging techniques.
Main Methods:
- Vitreous fluorophotometry was used to measure aqueous humor dye concentration.
- Fluorescein angiography was performed to detect leakage in the retina.
- Posterior vitreous penetration ratios were calculated and compared between affected and unaffected eyes.
Main Results:
- Aqueous humor dye concentration was elevated in affected eyes.
- No statistically significant difference was found in posterior vitreous penetration ratios.
- Fluorescein angiography revealed no leakage in either eye.
Conclusions:
- Disruption of the blood-retinal barrier is unlikely to be a primary factor in Berlin's edema.
- The term "commotio retinae" is recommended until further evidence clarifies the blood-retinal barrier's role.