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Extended Noninvasive Glucose Monitoring in the Interstitial Fluid Using an Epidermal Biosensing Patch.
Ernesto De la Paz1, Abbas Barfidokht1, Samantha Rios1
1Department of Nanoengineering, University of California, San Diego, La Jolla, San Diego, California 92093, United States.
Analytical Chemistry
|September 3, 2021
Summary
A new skin-worn biosensor offers noninvasive glucose monitoring for diabetes management. This wearable technology extracts interstitial fluid for accurate, extended blood glucose tracking without discomfort.
Area of Science:
- Biomedical Engineering
- Electrochemical Biosensors
- Diabetes Technology
Background:
- Diabetes mellitus (DM) management requires effective glucose monitoring.
- Existing methods face challenges in continuous, noninvasive monitoring.
- Noninvasive glucose monitoring is a significant unmet need.
Purpose of the Study:
- To develop and evaluate a novel skin-worn, wireless electrochemical biosensor for noninvasive glucose monitoring.
- To assess the performance of the biosensor for extended on-body monitoring in individuals with and without DM.
Main Methods:
- A wearable platform integrating iontophoresis for interstitial fluid (ISF) extraction and an amperometric glucose biosensor.
- Screen-printed electrodes and a wireless electronic interface for data transmission.
- Clinical trials for prolonged (up to 8 hours) on-body glucose monitoring.
Main Results:
- The biosensor demonstrated good correlation between blood and ISF glucose concentrations.
- Successful monitoring of dynamic glucose changes after food consumption.
- No reported skin irritation or discomfort during prolonged use.
Conclusions:
- The developed noninvasive skin-worn biosensor provides a promising solution for extended glucose monitoring.
- This technology addresses limitations of previous platforms like GlucoWatch.
- It offers a potential advancement in diabetes management tools.
