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Updated: Oct 13, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Aryl Diazonium Salts: Powerful Arylating Agents for Catellani-Type ortho-Arylation
Ying Fu1, Yu-Xia Zhang1, Liang-Liang Guo1
1Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P. R. China.
Abstract:
The Catellani reaction provides an efficient synthetic approach to polyfunctionalized arenes. However, the selective ortho-arylating reagents employed in these reactions have been strictly limited to activated bromoarenes. As demonstrated in this work, aryl diazonium salts bearing both electron-donating and electron-withdrawing substituents, after in situ transformations with KI into the corresponding iodoarenes, were efficient arylating reagents for Catellani type ortho-arylation approaches.
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