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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Oct 11, 2025

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

Published on: May 10, 2012

Whole-brain steady-state CEST at 3 T using MR Multitasking.

Pei Han^1,2, Karandeep Cheema^1,2, Hsu-Lei Lee¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Magnetic Resonance in Medicine

|November 29, 2021

Summary

This summary is machine-generated.

This study introduces fast 3D steady-state chemical exchange saturation transfer (ss-CEST) imaging using MR Multitasking. This novel method achieves whole-brain coverage in under 6 minutes, enabling efficient CEST quantification.

Keywords:

APT MR Multitasking chemical exchange saturation transfer rNOE steady-state CEST

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Area of Science:

Magnetic Resonance Imaging
Biomedical Engineering
Medical Physics

Background:

Chemical Exchange Saturation Transfer (CEST) MRI is a valuable technique for assessing tissue characteristics.
Traditional CEST imaging can be time-consuming, limiting its clinical applicability.
Accelerating CEST acquisition is crucial for improving patient comfort and enabling advanced applications.

Purpose of the Study:

To develop and validate a fast 3D steady-state CEST (ss-CEST) imaging technique.
To leverage MR Multitasking for rapid whole-brain CEST acquisition.
To assess the feasibility of quantitative CEST mapping within a clinically relevant timeframe.

Main Methods:

A continuous acquisition sequence incorporating repetitive ss-CEST modules was designed.
Each module utilized a Gaussian saturation pulse followed by spoiler gradients and FLASH readouts.
3D Cartesian encoding and four-pool Lorentzian fitting were employed for image reconstruction and quantification.

Main Results:

Whole-brain 3D ss-CEST imaging was successfully performed at a spatial resolution of 1.7 x 1.7 x 3.0 mm³.
Acquisition time was significantly reduced to 5.6 seconds per saturation frequency offset.
A complete scan with 55 frequency offsets was achieved in 5.5 minutes, yielding consistent quantitative CEST maps.

Conclusions:

3D ss-CEST imaging with whole-brain coverage is feasible within 5.5 minutes at 3 Tesla using MR Multitasking.
This accelerated approach enhances the practicality of CEST MRI for clinical use.
MR Multitasking offers a promising avenue for efficient and quantitative CEST imaging.