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Updated: Oct 8, 2025

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Resveratrol as a Probable Multiheaded Treatment Approach for COVID-19

Roohollah Ahmadian1,2, Hossein Biganeh1,2, Yunes Panahi3

  • 1Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Advances in Experimental Medicine and Biology
|January 4, 2022
PubMed

Insights

Resveratrol, a natural polyphenol, shows promise in preclinical studies as a potential treatment to reduce the effects of the COVID-19 virus. Further research is needed to explore its therapeutic potential against the ongoing pandemic.

Area of Science:

  • * Biochemistry and Pharmacology
  • * Infectious Diseases and Virology

Background:

  • * The COVID-19 pandemic has caused significant global mortality and morbidity.
  • * Existing treatments are insufficient, necessitating the urgent development of new therapeutic strategies.
  • * The polyphenol resveratrol has demonstrated potential in various biological activities.

Purpose of the Study:

  • * To review preclinical evidence on the efficacy of resveratrol in combating COVID-19.
  • * To highlight the potential of resveratrol as a therapeutic agent against SARS-CoV-2.

Main Methods:

  • * Systematic review of preclinical studies investigating resveratrol's effects on COVID-19.
  • * Analysis of in vitro and in vivo experimental data.

Main Results:

  • * Preclinical studies indicate that resveratrol exhibits antiviral properties against SARS-CoV-2.
  • * Resveratrol demonstrates potential in mitigating key aspects of COVID-19 pathogenesis.
  • * Observed effects include modulation of inflammatory responses and inhibition of viral replication.

Conclusions:

  • * Resveratrol presents a promising therapeutic candidate for COVID-19 treatment.
  • * Further clinical investigation is warranted to validate these preclinical findings.
  • * Resveratrol could offer a novel approach to managing COVID-19 severity.
Keywords:
COVID-19Herbal medicineResveratrol

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