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Updated: Oct 4, 2025
14:18
Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
Published on: February 13, 2012
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Store-Operated Calcium Entry in the Cardiovascular System
1Department of Kinesiology, The University of Texas at Arlington, Arlington, TX, USA.
Advances in Experimental Medicine and Biology
|February 9, 2022
Summary
Store-operated calcium entry (SOCE) is crucial for cardiovascular health and disease. This review explores the SOCE machinery
Area of Science:
- Cardiovascular Physiology and Pathophysiology
- Cellular Calcium Signaling
Background:
- Calcium ions (Ca2+) are vital for cardiovascular function, regulating cardiac contraction and vascular tone.
- Established Ca2+ channels, pumps, and exchangers are well-understood components of cytosolic Ca2+ signaling.
- Store-operated calcium entry (SOCE) is a recently recognized, ubiquitous mechanism impacting cardiovascular health.
Purpose of the Study:
- To review the current knowledge on the store-operated calcium entry (SOCE) machinery.
- To highlight the role of SOCE in maintaining normal cardiac and vascular function.
- To elucidate the contribution of SOCE to cardiovascular disease development and progression.
Main Methods:
- Literature review of studies on SOCE in cardiovascular contexts.
- Analysis of the molecular components and regulation of the SOCE machinery.
- Synthesis of evidence linking SOCE to cardiovascular pathogenesis and pathology.
Main Results:
- SOCE plays a significant role in both normal cardiovascular physiology and disease states.
- Dysregulation of SOCE contributes to the development and progression of cardiovascular pathologies.
- The SOCE machinery represents a potential therapeutic target for cardiovascular diseases.
Conclusions:
- Store-operated calcium entry (SOCE) is an essential mechanism in cardiovascular function and disease.
- Further research into SOCE is warranted to understand its full therapeutic potential in cardiovascular medicine.
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