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Related Concept Videos

Chronic Obstructive Pulmonary Disease-V: Management01:29

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
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Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Updated: Sep 29, 2025

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Targeting COPD with PLGA-Based Nanoparticles: Current Status and Prospects.

Juhi Saxena1,2, Monish Bisen2, Aditya Misra2

  • 1Department of Biotechnology, University Institute of Biotechnology, Chandigarh University, Mohali, Punjab 140413, India.

Biomed Research International
|March 21, 2022
PubMed
Summary
This summary is machine-generated.

Poly lactic-co-glycolic acid (PLGA) nanoparticles offer a safer, more effective approach to treating chronic obstructive pulmonary disease (COPD). These nanoparticles improve drug delivery, minimizing side effects and costs associated with traditional COPD therapies.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Respiratory Medicine

Background:

  • Chronic obstructive pulmonary disease (COPD) involves airflow blockage, free radical generation, and chronic inflammation, leading to significant global mortality.
  • Current COPD treatments like anti-inflammatories, antioxidants, and corticosteroids have limitations including high dosage requirements and severe side effects.
  • Nanomaterial-conjugated drugs show potential for respiratory diseases, requiring lower doses, reducing costs, and enabling targeted delivery with fewer side effects.

Purpose of the Study:

  • To review the pathophysiological mechanisms of COPD.
  • To highlight the role and potential of Poly lactic-co-glycolic acid (PLGA) nanoparticles in COPD therapy.
  • To discuss the current status of drug-loaded PLGA nanoparticles for COPD treatment.

Main Methods:

  • Review of existing literature on COPD pathogenesis.
  • Analysis of the application of Poly lactic-co-glycolic acid (PLGA) nanoparticles in drug delivery systems.
  • Evaluation of studies on PLGA nanoparticles for treating respiratory diseases, specifically COPD.

Main Results:

  • PLGA nanoparticles are safe, with metabolizable breakdown products.
  • Drugs loaded onto PLGA nanoparticles exhibit anticancer, antimicrobial, antioxidant, and anti-inflammatory properties.
  • Surface modification of PLGA nanoparticles can enhance their properties and therapeutic efficacy.

Conclusions:

  • PLGA nanoparticles represent a promising platform for targeted drug delivery in COPD therapy.
  • Drug-loaded PLGA nanoparticles offer a potentially safer and more effective alternative to conventional COPD treatments.
  • Further research into surface-modified PLGA nanoparticles could optimize COPD treatment strategies.