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The Impact of Obesity in Heart Failure

Salvatore Carbone1, Carl J Lavie2, Andrew Elagizi2

  • 1Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace St, 500 Academic Centre, Room 113c, Richmond, VA 23220, USA; Department of Internal Medicine, Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad St, Richmond, VA 23219, USA.

Cardiology Clinics
|April 25, 2022
PubMed

Insights

Overweight and obesity negatively affect heart function. However, individuals with heart failure who are overweight or obese show a better prognosis, especially when cardiorespiratory fitness is high.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Exercise Physiology

Background:

  • Overweight and obesity are linked to adverse cardiac structure and function, impacting both systolic and diastolic ventricular performance.
  • Epidemiologic studies reveal an 'obesity paradox' in heart failure patients, where excess weight correlates with better short- to medium-term outcomes compared to leaner individuals.

Purpose of the Study:

  • To explore the relationship between obesity, cardiorespiratory fitness, and prognosis in heart failure.
  • To discuss therapeutic implications for managing heart failure in the context of obesity.

Main Methods:

  • Analysis of epidemiologic data from large heart failure cohorts.
  • Examination of the influence of cardiorespiratory fitness levels on the obesity paradox.

Main Results:

  • The obesity paradox in heart failure is significantly modulated by cardiorespiratory fitness.
  • Higher cardiorespiratory fitness mitigates the negative impacts of obesity on heart failure prognosis.

Conclusions:

  • Therapeutic strategies should consider weight management, dietary improvements, and enhancing lean mass to improve cardiorespiratory fitness in heart failure patients with obesity.
  • Improving cardiorespiratory fitness is crucial for optimizing outcomes in obese heart failure patients.

Keywords:
Body compositionCardiorespiratory fitnessHeart failureObesityObesity paradox

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