Roles for GADD45 in Development and Cancer
Kishan Patel1, Mary Grace Murray1, Kelly A Whelan2,3
1Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Advances in Experimental Medicine and Biology
|May 3, 2022
Summary
Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins are key stress sensors involved in DNA repair and cell cycle control. This review explores their roles in normal development and cancer, highlighting knowledge gaps for improved cancer therapies.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- The Growth Arrest and DNA Damage-inducible 45 (GADD45) protein family acts as crucial stress sensors.
- These proteins regulate essential cellular processes like DNA repair, cell cycle arrest, and apoptosis.
Purpose of the Study:
- To review the literature on GADD45 family members in normal development and carcinogenesis.
- To consolidate current knowledge and identify research gaps concerning GADD45 biology.
Main Methods:
- Literature review of studies on GADD45 modulation in model organisms.
- Analysis of current research on GADD45 in human cancer, including expression alterations, tumor suppressive/promoting functions, and therapeutic roles.
Main Results:
- GADD45 proteins play significant roles in development and homeostasis, as shown by studies in model organisms.
- GADD45 family members exhibit dual roles in cancer, acting as both tumor suppressors and promoters, with altered expression in malignancies.
- GADD45 proteins are implicated in various cancer therapy strategies.
Conclusions:
- Understanding GADD45 functions in development, homeostasis, and carcinogenesis is critical.
- Further research into GADD45 biology can guide novel diagnostic, monitoring, and therapeutic approaches for human cancers.
Keywords:
CancerDevelopmentDrosophilaGADD45HomeostasisMouseOryctolagusTherapyTumor suppressorXenopusZebrafishMore Related Videos
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