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Updated: Sep 24, 2025
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
10.4K
Solid forms and β-cyclodextrin complexation of turinabol
Alexandru Turza1, Adelina Ulici2, Marieta Muresan-Pop3
1Mass Spectrometry, Chromatography and Applied Physics, National Institute for R&D of Isotopic and Molecular Technologies, Donat 67-103, PO 5 Box 700, 400293 Cluj-Napoca, Romania.
Summary
Researchers explored new solid forms of the anabolic steroid turinabol, including hydrates and solvates. Structural analysis revealed distinct molecular arrangements and interactions in these crystalline forms.
Area of Science:
- Solid-state chemistry
- Crystallography
- Pharmacology
Background:
- Turinabol (4-Chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one) is a synthetic anabolic-androgenic steroid.
- Understanding the solid-state properties of such compounds is crucial for their characterization and potential applications.
Purpose of the Study:
- To synthesize and characterize novel solid forms of turinabol.
- To elucidate the crystal structures and intermolecular interactions of these new forms.
- To investigate the complexation of turinabol with β-cyclodextrin.
Main Methods:
- Recrystallization from various solvents to obtain new solid forms.
- Single-crystal X-ray diffraction for absolute structure determination.
- Powder X-ray diffraction, FT-IR spectroscopy, and DTA/TGA for complex characterization.
Main Results:
- Four new solid forms of turinabol were obtained: hemihydrate, anhydrous, acetic acid hydrate, and trifluoroethanol hemisolvate.
- Crystal structures revealed differences in molecular packing, with some forms containing two molecules in the asymmetric unit.
- Complexation with β-cyclodextrin yielded a characterized complex.
Conclusions:
- The study successfully identified and characterized novel crystalline forms of turinabol.
- Detailed structural analysis provided insights into steroid conformation and intermolecular forces.
- The complexation study suggests potential for modified drug delivery systems.
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