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Speckle-resolved optical coherence tomography for mesoscopic imaging within scattering media
Michelle Cua1,2, Baptiste Blochet1, Changhuei Yang1,3
1Department of Electrical Engineering, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91152, USA.
Biomedical Optics Express
|May 6, 2022
Summary
Speckle-resolved optical coherence tomography (srOCT) efficiently detects forward-scattered
Area of Science:
- Biomedical Optics
- Optical Imaging
- Scattering Media Imaging
Background:
- Light scattering limits deep imaging in biological tissues.
- Multiply scattered light contains deeper sample information.
- Forward-scattered 'snake' photons offer a path for deeper imaging.
Purpose of the Study:
- To develop a novel technique for efficient detection of 'snake' photons.
- To enable depth-resolved imaging beyond the ballistic limit in scattering media.
Main Methods:
- Speckle-resolved optical coherence tomography (srOCT) system developed.
- Combines spatio-angular filtering with speckle-resolved interferometric detection.
- Selectively detects weakly scattered 'snake' photons.
Main Results:
- Demonstrated depth-resolved imaging beyond the ballistic limit.
- Achieved imaging up to 90 mean free paths (MFPs) in a phantom.
- Imaged 4.5 mm deep in chicken tissue with 0.4 mm resolution.
Conclusions:
- srOCT enables efficient detection of 'snake' photons.
- The technique significantly extends imaging depth in scattering media.
- Provides high-resolution depth-resolved imaging in biological tissues.
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