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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Sep 23, 2025

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
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Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

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HDL and microRNAs.

Hongtu Cui1, Kaixuan Lv2, Nana Yang3

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed
Summary
This summary is machine-generated.

High-density lipoproteins (HDLs) and microRNAs (miRNAs) play crucial roles in preventing metabolic diseases. Understanding their interaction offers new therapeutic strategies.

Keywords:
Circulating microRNAsHDLsMetabolic diseasesmicroRNAs

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • High-density lipoproteins (HDLs) are key in preventing metabolic diseases by influencing cellular pathways.
  • MicroRNAs (miRNAs) also impact HDL biogenesis, metabolism, and function, beyond traditional genes.
  • HDLs serve as effective carriers for miRNAs in the bloodstream.

Purpose of the Study:

  • To summarize microRNAs (miRNAs) that regulate high-density lipoprotein (HDL) functions.
  • To explore the role of miRNAs in HDL-mediated cellular processes.
  • To highlight the potential of HDL-miRNA interactions in metabolic disease treatment.

Main Methods:

  • Literature review and synthesis of existing research on miRNAs and HDLs.
  • Tabulation of miRNAs identified as regulators of HDL functions.
  • Analysis of HDL's role as a miRNA delivery vector.

Main Results:

  • Identified and summarized various miRNAs involved in regulating HDL functions.
  • Demonstrated that HDLs can transport miRNAs to target cells like macrophages and endothelial cells.
  • Established a connection between HDL-associated miRNAs and cellular responses relevant to metabolic health.

Conclusions:

  • MicroRNAs significantly influence HDL functions and metabolism.
  • HDLs act as crucial carriers for miRNAs, delivering them to specific cell types.
  • Further understanding of HDL-miRNA interactions provides novel therapeutic targets for metabolic diseases.